Sheetal Umrajkar, Mohammed Shakir Ghouse


The Transdermal drug delivery system (TDDS) can be defined as a delivery device, which upon application on a suitable skin surface will be able to deliver the drug into the systemic circulation at sufficient concentration to ensure therapeutic efficacy, an additional limitation to oral drug delivery, can be avoided with transdermal administration. Topical  administration  of  therapeutic  agents  offer  many  advantages  over  conventional  oral  and  invasive methods  of  drug  delivery.   Transdermal drug delivery systems deliver the drug through the skin in a predetermined and controlled rate. Basic components of this system include polymer matrix, membrane, drug, penetration enhancers, pressure-sensitive adhesives, backing laminates, release liner, etc. Transdermal patches can be divided into various systems like reservoir system, matrix system and micro-reservoir system, which are used to incorporate the active ingredients into the circulatory system via the skin. Several important advantages of transdermal drug delivery are enhancement of therapeutic efficiency and maintenance of steady plasma level of the drug.  During  the  past  decade,  the  number  of  drugs  formulated  in  the  patches  has  hardly increased,  and  there  has  been  little  change  in  the composition of the patch systems. Modifications have been mostly limited to refinements of the materials used.  This review explores the overall study on transdermal drug delivery system.


Penetration enhancer, pressure sensitive adhesives, reservoir system, transdermal, drug delivery

Full Text:

Full text in pdf


  • There are currently no refbacks.

Copyright © 2015 BIOPHARM JOURNAL  - ISSN 2454-1397 & Powered by Sona Nfinity