DESIGN AND DEVELOPMENT OF OIL-IN-WATER MICROEMULSION USING LONG AND MEDIUM CHAIN TRIGLYCERIDES TO INCREASE THE SOLUBILITY OF ACECLOFENAC

Sandeep Sankar Acharya, Bibaswan Mishra, Kalinga Kalia Lenka

Abstract


Aceclofenac is a Non steroidal anti-inflammatory drug against rheumatoid arthritis. The poor solubility of aceclofenac in water limits its oral bioavailability. In this study, oil-in-water (O/W) system of microemulsion prepared and optimised with a view to their use as solubility enhancers. Therefore, different surfactants of Tween, Chremophor, Labrasol were tested to solubilise the drug with medium chain triglycerides. The pseudoternary phase diagrams reveal the suitability of selection of oils, surfactant and cosurfactant. The microemulsion characterised by mean droplet sizes about 87 nm were successfully produced. They were able to improve the drug solubility up to 1000-fold. Rheological studies having Newtonian fluid behaviour represents the optimal viscosity of the formulation. The zeta potential of -45mv is showing the stability of microemulsion. The in-vitro drug diffusion of microemulsion through semipermeable membrane was compared with marketed formulation. The anti inflammatory action of the formulation and the in-vivo absorption study investigation conducted in rat were significant. Finally the accelerated stability of optimised formulation passed the tests.


Keywords


Aceclofenac, Oils, Microemulsions, Surfactants, Psedoternary Phase diagram

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References


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