EFFECT OF DRUG SOLUBILITY AND LIPID CARRIER ON DRUG RELEASE FROM NANOSTRUCTURED LIPID CARRIERS

N. J. Maiti, M.Dey Dey, B. Barik, A. Malana, A. Dinda, A. Patel

Abstract


The present work is aimed at investigations of the effects drug solubility and lipid carrier of drug (dexamethasone and diclofenac) loaded nanoparticles. Nanoparticles were prepared by high shear homogenization technique. The effects of drug solubility and process parameters were studied. Investigations were also carried out regarding influences of different homogenization parameters (pressure and number of cycles) on the properties of various nanoparticles. Various properties of nanoparticles subjected to investigations include, particle size, drug loading, the drug release profile and DSC. These properties were found to be strongly influenced by the nature of solubility of drug.


Keywords


Solid lipid nanoparticles, Nanostructured lipid carriers, Dexamethasone, Diclofenac

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