Ashish Gawai, S. K. Magar, D. R. Gaikwad, K.R. Biyani


Inflammation is reaction of vascular and supporting element of a tissue to injury, and result in formation of protein rich exudates, provided the injury has not been so severe as to destroy the area. In pharmacological evaluation the anti-inflammatory activity was studied using carrageenan induced rat paw edema method. Initial paw volume was measured and 1% carragenan solution was injected in right hind paw of rats. The animals were maintained under good hygienic conditions. The animals were divided into 6 groups. The observations were made at 30 min, 60 min, 90 min, 120 min, 150 min, and 180 min. respectively and the observation were studied. Diclofenac sodium gel shows 98% edema inhibition after 3 hrs with respect to control group, where as F-I (Carbopol gel base) shows 92% edema inhibition, and F-II (Carbopol gel base) 96% edema inhibition respectively. In pharmacological evaluation the anti-inflammatory activity was studied using Cotton pellet induced granuloma method. Cotton pellet are inserted in groin region of rat and standard and various polyherbal drug conc. are given by oral route. The observation is made by weighing the dried cotton pellet. Diclofenac sodium shows 50% of inhibition with respect to control group, Test 1 shows 39.75%, Test 2 shows 43.45% inhibition, and Test 3 shows 48.82% inhibition.


Inflammation, carrageenan, granuloma

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