DEVELOPMENT, OPTIMIZATION AND CHARACTERIZATION SELFEMULSIFIED TABLET OF SIMVASTATIN

Abdul Karim Ahammad, Nihar Ranjan Pani

Abstract


The hypothesis of the present investigation is the eutectic interaction between a therapeutic entity and a eutectic agent could be utilized to prepare and formulate superior lipid based and solid-state self-emulsified dosage forms (SEDF). In the present study, Simvastatin was employed as a model drug (mg) and essential oils (Lineloic acid) were evaluated as the eutectic agents. A conventional tablet of Simvastatin was developed and optimized through 23 factorial designs by incorporating drug into solid lipid based self- emulsified formulation to enhance the bioavailability of drug. The objective of current research is to enhanced the bioavailability of lipophilic model drug, simvastatin by the developing the SEDF. The tablet of SEDF was intended to develop and to increase the   stability of the formulation. The formulae of SEDF tablet of Simvastatin were optimized through 23factorial design by using concentration of, Cross carmelose sodium (CCS), Maltose and microcrystalline cellulose (MCC) as three independent variables and drug release at 5min (DR5), drug release at 30min (DR30), drug release at 60min (DR60) as three dependent variables. The tablets were evaluated for weight variation, thickness, hardness, friability, disintegration test, dissolution test. The in vitro dissolution study  of F6 containing 70mg/tab, 100mg/Tab, 30mg/tab amount of c.c.s, maltose, MCC respectively, reveals the desired dissolution profile  according to pharmacopeia consideration.(>85 % of drug release at 30min).


Keywords


Simvastatin, Selfemusified tablet, Optimization, Drug release

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