EVALUATION OF BINDING PROPERTIES OF NATIVE AND MODIFIED STARCHES DERIVED FROM Solenostemon rotundifolius IN PARACETAMOL TABLET FORMULATIONS

A R Oduola, H Musa, T S Allagh, M S Gwarzo, I V Emenike

Abstract


This study was aimed at evaluating the binding properties of Solenostemon  rotundifolius starch (SRS)  and modified forms of it in comparison with gelatin B.P., for use as pharmaceutical excipient by wet granulation method of tablet production. Paracetamol, a high dose poor water-soluble drug was used in formulation. Granule properties such as Angle of repose, Moisture content, Bulk and Tapped densities, Hausner’s ratio and Carr’s index revealed that increase in concentration of starches tested as binder led to improvement in flow characteristics. Mucilages of the tested starches and gelatin of varying concentrations of 0, 5.0, 7.5, 10.0 and 12.5 % w/w were used to produce paracetamol granules by wet granulation method and compressed into tablets. Tablet properties which included weight uniformity, friability, crushing strength were carried out. An increase in binder concentration in the tablet led to a decrease in friability and an increase in crushing strength. The results revealed that pregelatinised starches are better binders and that SRS and the modified starches could be used at 7.5%w/w as binders. Thus, in tablet formulation pregelatinising Solenostemon rotundifolius starch makes it a suitable binder with high bond strength and could be useful in formulation of tablets with desired mechanical properties for various purposes.

 


Keywords


Evaluation, Binding Properties, Solenostemon rotundifolius, Starch, Paracetamol.

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